Kisspeptin-10
Kisspeptin-10 (Metastin 45-54)
GnRH stimulator — HPG axis activator
About
A 10-amino-acid peptide that activates Kiss1R receptors in the hypothalamus, the strongest natural activator of GnRH. Studied for hypogonadism and low testosterone.
Mechanism
Binds Kiss1R receptors on GnRH neurons, triggering an LH and FSH pulse and then testosterone or estradiol release.
Dosage
Draw to 2 units on a U-100 insulin syringe
5 mg · 2 mL BAC
When to take: Best in the morning when natural hormone pulses are activating.
Reconstitution
Vial size (mg): 5 mg · BAC water (mL): 2 mL · Concentration: 2500 mcg/mL
A large bac volume yields convenient small doses. Very fragile — the peptide degrades quickly.
Dosing reference
Units to draw at the typical dose range, per vial size.
| Vial | Water | Typical draw |
|---|---|---|
| 5 mg | 2 mL | 4–8 units |
| 10 mg | 2 mL | 2–4 units |
Benefits
- Naturally raises LH and FSH
- Improved libido (both sexes)
- Raises testosterone (men)
- Possible fertility boost
- Gentler than HCG (no desensitization)
Side effects
- Headache
- Flushing and warmth
- Rare: nausea
- Well tolerated at low doses
Gender notes
Cautions
- Hormone-sensitive cancers
- Pregnancy
- Pituitary tumor
- Use of tamoxifen or aromatase inhibitors
Research
- Comninos et al: Kisspeptin in HSDD women
JCI Insight · 2020
Clinical trial in women with low sexual desire — improved arousal and response.
- George et al: Kisspeptin in male testosterone
J Clin Endocrinol Metab · 2011
In men — activates LH naturally, stronger than a GnRH analog.